If the entourage effect is real, how effective can CBD be if you don’t bring a little THC along for the ride?
Can CBD work without THC? Of course, we have studies to suggest CBD works effectively as a stand-alone cannabinoid. 
But what about the entourage effect? Doesn’t CBD need other cannabinoids, terpenes and flavonoids to be effective?
We’ll explore some of the latest research on the topic. However, before we get started, we think it’s important to point out that we always advocate using full-spectrum products as opposed to isolate products.
How does CBD work without THC
How does CBD oil work without THC? Simple, by interacting with the serotonin 5-HT1A receptor.
OK, maybe not so simple.
Researchers are still discovering how serotonergic systems relate to the endocannabinoid system. But if results are any indication, CBD can reduce anxiety and symptoms related to inflammation.
CBD oil works without THC just fine. There’s no need to understand the nuances of 5-HT1A receptors, TRPV1 proteins, or allosteric modulators.
But if you insist, here’s a brief explanation.
CBD interacts with 5-HT receptors that are part of a “super family” of G-protein receptors in the brain and body. These neurotransmitter systems are associated with pain relief and reduced anxiety.
THC binds to our CB1 and CB2 receptors, making users feel “high.” CBD doesn’t bind directly to these receptors.
CBD doesn’t compete for cannabinoid receptors in your brain. But does it interfere with THC? That is, will the presence of CBD in your system alter THC benefits?
We’ll get to that below. But first, we’ll answer, “does CBD without THC work?”
Does CBD without THC work?
Does CBD work without THC present in your system? It depends on what you mean by “work” and “present.”
A full-spectrum CBD product with 1% THC isn’t going to get you “high.” Unlike a similar product with a split 50/50 THC: CBD ratio.
What do you need CBD for? Someone with chronic pain may prefer more THC in their product than someone looking to reduce anxiety.
You can find CBD with melatonin added to help sleep on the Australian green market. One can find a range of high-quality products if they do their research.
So, depending on your needs, CBD can work without THC. Cannabidiol, on its own, works in clinical studies and anecdotally.
But CBD without THC benefits means you’ll miss the entourage effect.
For example, research shows THC reduces anxiety in low doses. So if you’re avoiding full-spectrum products due to THC content, you might want to rethink your decision.
Do You Need Other Cannabinoids to Make CBD Work?
The entourage effect says cannabinoids work better when they’re together.
Now, you don’t have to take anything but CBD (this is called a CBD isolate). But it won’t be as effective as full or broad-spectrum products.
CBD isolates lack the terpenes and flavonoids that help contribute to cannabis’ medicinal properties.
Research has found that terpenes and phytocannabinoids work together to help reduce:
- fungal infection
The author suggests terpenes and flavonoids are beneficial for the body and brain. They contribute the anti-inflammatory effects of cannabis to these phytocannabinoids.
According to research, cannabis terpenes may have neuroprotective properties, making full-spectrum cannabis a superior product.
More research is needed to determine if CBD oil is effective without THC. But CBD without THC benefits is incomplete.
What About THC without CBD?
Although this article is not the scope, it’s interesting that many connoisseurs have noted that CBD dulls their THC high.
What’s going on here? While it’s not entirely clear, it appears that CBD keeps our cannabinoid receptors from getting overly excited.
Is CBD Without THC Right for You?
Plenty of research supports CBD working by itself. How do you know which cannabinoid is right for you?
The best thing to do is talk to your health care provider. Technically this is the only way to get medical cannabis in Australia.
But it’s also a good idea if you’re on medication that may adversely react with CBD.
There are plenty of high-quality CBD products found on the green market. You can experiment with broad-spectrum, full-spectrum, and a CBD isolates product if all else fails.
Whatever you decide, the answer is yes: CBD works by itself.
But suppose you really want to ramp up the benefits of medical cannabis. In that case, you should look at incorporating more than just CBD.
And that may include a little THC.